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. 2020 Feb 1;93(1106):20190496. doi: 10.1259/bjr.20190496

Table 3.

Role of 18F-FDG PETCT radiomics in head and neck cancers

Author and year of publication Patient sample size and disease stage Time of imaging and study type Therapy Number of parameters derived Method of feature grouping/selectionand number of parametrs derived Outcome parameter Result
Bogowicz et al16
May 2017
TC = 93 ; VC = 56
Stage III and IV HNSCC(Orp,Hyp,Lar,OC)
Pretreatment
Retrospective for TC
Prospective for VC
Definitive IMRT 70 Gy with cisplatin or cetuximab. Shape, Intensity, Texture, Wavelet transform
317 features
Grouping: PCA
Selection: UVCRA for prognosis (9)
For comparison with clinical and combined radiomics-clinical model: MVCRA(3)
Split ROC curves at 18 mths
Predict LC: using CI
Compare radiomics versus clinical model and a combined clinicoradiomic model for LC
Radiomics signature significantly associated with LC
Combined radiomics + clinical model performed better than radiomics model alone in TC, but not VC
Bogowicz et al28
June 2017
N = 172
TC = 121; VC = 51
Stage III and IV HNSCC(Orp,Hyp,Lar,OC)
Pretreatment
Retrospective for TC
Prospective for VC
Definitive IMRT 70 Gy with cisplatin or cetuximab TC
VC = TC+_ consolidation cetuximab
Shape, Intensity, Texture, Wavelet transform
569
Combination of feature selection using PCA and classification using Cox regression with backward selection: chosen for least complicated and best discriminatory.
Model validation: CI using Wilcoxon and bootstrap
Compare CT, PET, PETCT radiomics models for prognosis CT radiomics overestimates probability of tumor control in high risk group.
Mostly due to CT artifacts and variable contrast dose.
CT (GLSZM,HLH)
PET (Spherical disproportion, GLSZM)
Combined (CT HLH and PET GLSZM)
All showed similar discriminatory CI > 0.7
El Naqa et al27
June 2009
N = 9
Stage and type: NM
Pretreatment Retrospective
Median F/U period of 30 months.
Chemoradiotherapy (details not mentioned) IVH, Shape, Texture, SUV measures
18
RS and AUC for association between extracted features and post-radiotherapy outcomes.
Two-metric logistic regression model
Analyzed for endpoint of overall survival rate Shape-based metrics had the highest categorical prediction power, while commonly used SUV descriptive statistics had the lowest predictive ability
Cheng et al26
Sept 2013
N = 70
T3-4 OPSCC
Follow up: 24 mths
In-house (Matlab)
Pretreatment
Retrospective
Completed platinum-based CCRT, cetuximab-based CBRT, or RT alone with curative intent SUV histogram, TLG, NGLCM, NGTDM MVCRA to identify the independent predictors of PFS, DSS, and OS
RS to evaluate the associations between textural characteristics, SUVmax, MTV, TLG, and the general characteristics of the study participants.
Can textural features provide any additional prognostic information over TLG and clinical staging Uniformity extracted from the normalized gray-level cooccurrence matrix found to be an independent prognostic predictor
Cheng et al25
Oct 2014
N = 88
T3 or T4 OPSCC
In-house (Matlab)
Pretreatment
Retrospective
83 patients received CCRT, three received BRT, and the remaining two patients received RT alone with curative intent. SUV, TLG, GLRLM, GLSZM UV and MVCRA to identify the independent predictors of PFS and DSS.
Kaplan-Meier curves for survival.
Prognostic impact of regional heterogeneity on Progression-free survival (PFS) and disease-specific survival (DSS) Zone-size nonuniformity (ZSNU) identified as an independent predictor of PFS and DSS.
Model combining total lesion glycolysis, uniformity and ZSNU showed a higher predictive value than each variable alone