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. Author manuscript; available in PMC: 2020 Aug 19.
Published in final edited form as: Nature. 2020 Feb 19;578(7796):610–614. doi: 10.1038/s41586-020-2028-z

Extended Data Fig. 5.

Extended Data Fig. 5

TGFβ blocking sensitize mice to acute cold exposure

a, Decreased lipid accumulation in the TGFβ1-AAV treated BAT (H&E histology). Data represent 2 independent experiments with similar results. b, WT mice treated with TGFβ neutralizing antibody for 3 weeks are sensitive to cold exposure(n=6 mice). c, WT mice treated with TGFβ inhibitor for 3 weeks are sensitive to cold exposure(n=8). d, e, Forced expression of TGFβ1-AAV increases the SG TH (d) and TUBB3 (e) immuno-staining in Il17rc KO mice (n=6 mice). f, g, Forced expression of TGFβ1-AAV increases SG TH and TUBB3 immuno-staining in Rag2 KO mice by TH(f) and TUBB3 (g) staining (n=6 mice). scale bar=50um. Data represent 2-3 independent experiments. Data are mean ± SEM and analyzed by unpaired Student’s two-sided t-test and Two-way ANOVA.