Figure 3.
Nanoparticle-based therapeutic for CVD. (a) Schematic representation of a reconstituted high-density lipoprotein (HDL) nanoparticle loaded with simvastatin ([S]-rHDL), along with an accompanying transmission electron micrograph. (b) Fluorescence molecular tomography/CT imaging of protease activity demonstrated that atherosclerotic mice treated with a high dose of [S]-rHDL had significantly reduced inflammation levels. (c,d) Quantification of mean plaque area (c) and plaque macrophage content (d) demonstrated the benefits of treatment with [S]-rHDL. Adapted with permission.136 Copyright 2014, Springer Nature.