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. 2020 Jan 23;7(5):1900860. doi: 10.1002/advs.201900860

Figure 1.

Figure 1

Level of PINK1‐dependent mitophagy markers (i.e., PINK1 and PARK2 expression) and correlation of PINK1‐dependent mitophagy with clinical outcomes in patients with MM. A,B) PINK1 and PARK2 expression levels in MGUS plasma cells and myeloma cells in the A) Arkansas and B) Mattiloli datasets. Expression levels were presented as scatter plot and were compared using an unpaired Student's t‐test. C,D) Kaplan–Meyer analysis of overall survival in the Heidelberg/Montpellier dataset basing on the expression of PINK1 and PARK2 in CD138+ cells of myeloma patients. Survival analysis was performed using a log‐rank test. High and low PINK1 expression (ID: 209019_s_at) was defined using a cut‐off of 660. High and low PARK2 expression (ID: 1554855_at) was defined using a cut‐off of 11. E,F) Kaplan–Meyer analysis of event‐free survival in the Heidelberg/Montpellier dataset basing on the expression of PINK1 and PARK2 in CD138+ cells of myeloma patients. Survival analysis was performed using a log‐rank test. High and low PINK1 expression (ID: 209019_s_at) was defined using a cut‐off of 1202. High and low PARK2 expression (ID: 1554855_at) was defined using a cut‐off of 11.