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. 2020 Jan 10;7(5):1901878. doi: 10.1002/advs.201901878

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© 2020 Brigham and Women's Hospital/Harvard Medical School. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Integration of the biosensing system with the 3D‐printed construct. a) Dual ink nozzles printing a nose on top of the sensor electrodes. b,c) CAD 3D drawing of the nose with dual ink layers (top) and the printed construct using the same code (bottom). d) Optical image of the microfabricated Au biosensor with three electrode sensing system (top) and 3D‐printed dual‐ink nose integrated with the biosensors in each nostril (bottom). e,f) Live/dead assay images of chondrocytes seeded on the biosensor to test biocompatibility on Au (e) and Ag (f) electrodes. g) Quantified cell viability graph on Au and Ag electrodes on day 1 after integration with cells. h) F‐actin/DAPI staining of the sensor 7 days after integration.