Table 1.

Enantioconvergent N-alkylation: Effect of reaction parameters.

entry	change from the “standard conditions”	ee (%)	yield (%)a
1	none	87	84
2	no Cu–Mes, no L*	–	8
3	no L*	–	55
4	L1, instead of L*	32	39
5	5 mol% Cu–Mes, 10 mol% L*	82	64
6	14, instead of 20, mol% L*	68	76
7	under air in a capped vial	83	67
8	0.1 equiv of water added	85	74

All data represent the average of two experiments.

^aDetermined through ¹H NMR spectroscopy, with the aid an Internal standard.