| Methods |
Randomised, double‐blind, placebo‐controlled trial |
| Participants |
84 children (age range 0.49 to 24.8 years) with measles. Separate data for children below 18 years (81 children) were obtained from trial authors |
| Interventions |
The treatment group received co‐trimoxazole. Children below 5 years of age and weighing < 18 kg received paediatric cotrimoxazole tablets 3 times a day and those above 5 years or > 18 kg received adult cotrimoxazole tablets twice a day. Control group received a placebo twice a day |
| Outcomes |
Treatment failure due to pneumonia, admission to hospital or both. Other morbidities |
| Notes |
2 participants in the treatment group and 1 patient in the control group received the wrong dose of the trial drug. A total of 87 participants were enrolled in the study. Follow‐up of 1 and 2 participants, respectively, was not available in the treatment and control groups and these participants were not included in the intention‐to‐treat analysis |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
Not clear from paper |
| Allocation concealment (selection bias) |
Low risk |
Double‐blind RCT |
| Blinding of participants and personnel (performance bias)
All outcomes |
Low risk |
Double‐blind randomized controlled trial |
| Blinding of outcome assessment (detection bias)
All outcomes |
Low risk |
Double‐blind randomized controlled trial |
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
All data shown |
| Selective reporting (reporting bias) |
Low risk |
None |
| Other bias |
Low risk |
None |
