Skip to main content
. 2020 Mar 4;6:11. doi: 10.1038/s41420-020-0245-8

Fig. 4. Oral metformin administration prevented the development of IMQ-induced psoriasiform eruptions.

Fig. 4

C57BL/6 mice were administered vehicle or metformin (100 and 200 mg/kg once daily) for 5 days from the day of topical application of IMQ to the left ear. a Clinical images of the ear. b Histology of the ear. Scale bar = 100 μm. c C57BL/6 mice were administered vehicle or metformin (200 mg/kg once daily) for 3 days from the day of topical application of IMQ to the ear. Then, mRNAs were extracted from the epidermis of the ear and IL-1β, IL-36γ, Cxcl1, Cxcl2, Ccl20, S100a7, S100a8 and S100a9 mRNA levels were analysed by qRT-PCR. a, b n = 6 for each group. c Data are expressed as mean ± SD; n = 6 for each group. *P < 0.05. a–c The data are representative of experiments repeated three times with similar results.