Table 1.

Linear Regression Analysis Comparing Contractile and Inflammatory Parameters with Viral Load

Variables Plotted (Fold Change vs. Control)	R2 Value	P Value
IP-10 release vs. RV-C15 detected	0.28	0.36
IL-6 release vs. RV-C15 detected	0.22	0.42
MIP-1β vs. RV-C15 detected	0.96	0.003
Change in sensitivity (Log EC50) vs. RV-C15 detected	0.29	0.35
Change in total response (AUC) vs. RV-C15	0.03	0.79
IP-10 release vs. change in total response (AUC)	0.14	0.53
IL-6 release vs. change in total response (AUC)	0.86	0.02
MIP-1β vs. change in total response (AUC)	0.05	0.71
Change in sensitivity (Log EC50) vs. IL-6 release	0.01	0.87
Change in sensitivity (Log EC50) vs. IP-10 release	0.06	0.69
Change in sensitivity (Log EC50) vs. MIP-1β release	0.45	0.45

Definition of abbreviations: AUC = area under the curve; IP-10 = IFN-γ–induced protein 10; Log EC₅₀ = log of effective concentration to induce 50% bronchoconstriction; MIP-1β = macrophage inflammatory protein-1β; RV-C15 = rhinovirus C15.

Data represent n = 5 separate donors.