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. Author manuscript; available in PMC: 2020 Mar 4.
Published in final edited form as: J Pancreatol. 2019 Dec;2(4):147–151. doi: 10.1097/jp9.0000000000000029

Figure 1.

Figure 1.

5-FU-miR-15a combined the tumor suppressive effects of miR-15a with those of 5-FU. 5-FU-miR-15a is incorporated into the RISC complex resulting in suppression of miR-15a’s target genes, Wee1, Chk1, BMI-1, and Yap-1. Suppression of these targets induces cell cycle arrest, apoptosis, and suppresses EMT. When the 5-FU-mIR-15a breaks down 5-FU is released which will lead to DNA damage and cell death. In addition the modification of the miRNA may have some novel effects resulting from the unique modification as well as its breakdown products. Chk1 = checkpoint kinase 1, EMT = epithelial-to-mesenchymal transition, 5-FU = 5-fluorouracil, miRNA = microRNA, RISC = RNA-induced silencing complex.