Figure 3:

Electroretinographic responses of mice with type 2 diabetes deprived of light for 3 months. Data in box plots are represented as median (line), IQR (box), and range (whiskers); n=>10 mice/group; db/db = type 2 diabetes group, db/m = age-matched healthy control group. A, Traces showing mean responses with SEM from representative mice that were light-deprived beginning at age 3 months until age 6 months (DARK) or kept in standard lighting (CTRL), showing isolated scotopic oscillatory potentials (OPs) recorded from a 0.983 cd·s/m² flash. B, Implicit times of the scotopic OPs. ** = P<0.01, *** = P<0.001, **** = P<0.0001, by 2-way RM ANOVA with Bonferroni post-hoc correction. C, Scotopic ERG traces recorded from a 0.983 cd·s/m² flash showing mean responses with SEM from a representative sample of diabetic mice (green) and littermate non-diabetic controls (blue). D, Amplitudes of scotopic a-wave responses from a maximal 7.846 cd·s/m² flash. P>0.05 for all comparisons using 1-way ANOVA and Bonferroni post-hoc correction. E, Luminance-response curve showing a-wave amplitudes in mice with or without diabetes, deprived of light or kept in standard lighting conditions. Data represent mean with SEM (error bars) and were analyzed by 2-way RM ANOVA with Bonferroni post-hoc correction. *=P<0.05, ***=P<0.001, comparing db/db CTRL and db/db DARK; ##=P<0.01, comparing db/db CTRL and db/m CTRL; †=P<0.05, ††††=P<0.0001, comparing db/db CTRL and db/m DARK; all other comparisons have P>0.05.