. Author manuscript; available in PMC: 2021 Apr 1.

Published in final edited form as: Neurobiol Dis. 2020 Jan 21;137:104754. doi: 10.1016/j.nbd.2020.104754

Table 1:

Metabolic data of light-deprived mice in a type 2 model of diabetes.

	12 hr ON: 12 hr OFF (Control)		24 hr OFF (Light-Deprived)

	Non-diabetic db/m	Diabetic db/db	Non-diabetic db/m	Diabetic db/db
n	21	19	22	20
Body Weight, g, 3 months (at randomization)	22.9 (0.9)	51.1 (1.3)^****	24.1 (0.6)	51.1 (0.6)^****
Body Weight, g, 6 months (at assay)	27.2 (1.0)	62.0 (1.6)^****	27.0 (0.7)	58.5 (1.6)^****
Random Plasma Glucose, mg/dL, 3 months (at randomization)	126.7 (7.3)	414.3 (17.4)^****	131.6 (4.1)	462.1 (26.7)^****
Random Glucose (mg/dL) 6 months (at assay)	130.8 (5.9)	522.7 (23.5)^****	134.8 (5.2)	559.4 (28.0)^****
Fasting Plasma Glucose (mg/dL) 6 months	135.5 (4.8)	645.2 (5.9)^****	142.5 (7.3)	621.2 (10.3)^****
Glucose Tolerance Testing (AUC) at 6 months	16506.5 (1330.4)	89026.3 (3897.3)^****	17060.3 (1611.8)	81051.7 (6989.4)^****
Fasting Insulin at 6 months	0.47 (0.02)	2.37 (0.23)^**	0.9 (0.05)	2.78 (0.21)^**

Measures were taken at the time of randomization to control lighting or light-deprivation, and again at the time of the assay. Data are represented as mean (SEM) and groups were compared by 1-way (for GTT AUC and Fasting Insulin) or 2-way (for body weight and glucose) ANOVA with Bonferroni post-hoc correction.

^**

= P<0.01

^****

= P<0.0001 compared to healthy littermates within same lighting group; P>0.05 for all other comparisons.