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Osteosclerosis grading in bone marrow tissue. From left to right: bone marrow biopsy sections for each grade from grade 0 to grade 3, and each section is stained with H&E stain and imaged at 10× magnification. Grade 0 shows normal trabecular bone in BM. Grade 1 shows initial trabecular apposition though focal budding. Grade 2 shows abnormal growth with thickening and diffuse trabecular structure. Grade 3 shows extensive interconnected new bone growth with effacement of marrow space.
