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. Author manuscript; available in PMC: 2021 Jan 7.
Published in final edited form as: Anal Chem. 2019 Dec 13;92(1):749–757. doi: 10.1021/acs.analchem.9b03015

Figure 8.

Figure 8.

Box plots for the proposed metrics for automated osteosclerosis grading based on 19 tissue samples: (a) trabecular bone area (TBA), percentage of trabecular bone area with respect to total tissue area; (b) diffusion metric (N), count of nonfragmented trabecular bone structures contributing; (c) spacing between trabecular bone structures (AS), spacing defined in pixels where pixel size is 5.5 μm2; (d) clinical separation metric (CS), combination of three metrics mentioned earlier (TBA + N – AS), clearly separating samples into two groups, one with grades 0 and 1 samples and the other with grades 2 and 3 samples.