Table 2.
Multivariable regression models for the determinants of 24-hour urinary norepinephrine and epinephrine excretion rates during isocaloric conditions
| Urinary Norepinephrine (μg/24h) Log10-transformed | Urinary Epinephrine (μg/24h) Log10-transformed | |
|---|---|---|
| Explained variance (global P value) | R 2 =0.20 P < .001 | R 2 =0.16 P = .004 |
| Age, y | 0.002 ± 0.002 | –0.001 ± 0.002 |
| (–0.001, 0.005) | (–0.004, 0.002) | |
| Partial r: 0.105 | Partial r: –0.032 | |
| P = .16 | P = .67 | |
| Sex (male) | 0.06 ± 0.05 | 0.1 ± 0.05 |
| (–0.03, 0.15) | (0.01, 0.19) | |
| Partial r: 0.09 | Partial r: 0.16 | |
| P = .21 | P = .03 | |
| Ethnicity (White) | –0.1 ± 0.12 | –0.11 ± 0.12 |
| (–0.34, 0.13) | (–0.35, 0.12) | |
| Partial r: –0.07 | Partial r: –0.07 | |
| P = 0.38 | P = 0.33 | |
| Ethnicity (Native American) | –0.05 ± 0.12 | –0.15 ± 0.12 |
| (–0.28, 0.18) | (–0.39, 0.08) | |
| Partial r: –0.03 | Partial r: –0.1 | |
| P = .65 | P = .20 | |
| Ethnicity (black) | –0.08 ± 0.12 | –0.03 ± 0.12 |
| (–0.32, 0.16) | (–0.27, 0.21) | |
| Partial r: –0.05 | Partial r: –0.02 | |
| P = .50 | P = .81 | |
| Ethnicity (Hispanic) | –0.05 ± 0.12 | –0.03 ± 0.12 |
| (–0.29, 0.19) | (–0.27, 0.22) | |
| Partial r: –0.03 | Partial r: –0.02 | |
| P = .70 | P = .83 | |
| Percentage body fat (%) | 0.001 ± 0.003 | –0.003 ± 0.003 |
| (–0.005, 0.006) | (–0.008, 0.003) | |
| Partial r: 0.021 | Partial r: –0.073 | |
| P = .78 | P = .33 | |
| Fasting glucose | 0.002 ± 0.002 | –0.0014 ± 0.0022 |
| (–0.003, 0.006) | (–0.0058, 0.003) | |
| Partial r: 0.052 | Partial r: –0.0465 | |
| P = .49 | P = .53 | |
| Fasting insulin(log10- transformed) | 0.22 ± 0.06 | 0.03 ± 0.06 |
| (0.11, 0.34) | (–0.08, 0.14) | |
| Partial r: 0.28 | Partial r: 0.04 | |
| P = 0.001 | P = .59 | |
| Storage time, mo | 0.00003 ± 0.00002 | 0.000004 ± 0.000019 |
| (–0.00001, 0.00006) | (–0.000034, 0.000041) | |
| Partial r: 0.11 | Partial r: 0.01 | |
| P = .16 | P = .85 | |
| Intercept | 0.52 ± 0.46 | 0.73 ± 0.47 |
| (–0.4, 1.44) | (–0.19, 1.66) | |
| P = .26 | P = .12 |
The β coefficient estimate in each cell is reported with ± SE and the 95% CI in parentheses, along with partial correlations and P value. Significant results are highlighted in bold.
Similar results were obtained when introducing the 3-hour total area under the curve (AUC) of the insulin/glucose response during the oral glucose tolerance test (model with norepinephrine: AUC insulin: partial r = 0.21, P = .005) into the linear model in place of fasting insulin/glucose, when introducing body mass index in the linear model in place of percentage body fat, and after excluding individuals with impaired glucose tolerance (n = 65).