Table 1.
Patient characteristic | Physician diagnosis | |||
|
RRMS (n=89) | Transitioning (n=47) | SPMS (n=62) | |
Age (years) |
|
|
|
|
|
n | 89 | 47 | 62 |
|
Mean (SD) | 38.1 (11.3) | 46.2 (10.7) | 53.4 (10.7) |
|
Median (range) | 37 (19-66) | 47 (28-68) | 52 (34-78) |
EDSS score |
|
|
|
|
|
n | 81 | 47 | 61 |
|
Mean (SD) | 2.6 (1.0) | 4.3 (1.1) | 5.6 (1.4) |
|
Median (range) | 2 (0-7)b,c | 4 (2-7) | 6 (3-9) |
Patients with relapses in the past 6 months, n | ||||
|
Yes | 30 | 10 | 9 |
|
No | 59 | 37 | 53 |
Duration since RRMS diagnosis (years) |
|
|
|
|
|
n | 89 | 47 | 62 |
|
Mean (SD) | 7.3 (6.3) | 13.2 (8.4) | 17.3 (10.1) |
|
Median (range)d | 5.0 (0-26) | 11.3 (0-37) | 15.8 (0-51) |
Duration since SPMS diagnosis (years) |
|
|
|
|
|
n | — | — | 62 |
|
Mean (SD) | — | — | 6.3 (5.3) |
|
Median (range)d | — | — | 5 (0-22) |
aPhysician diagnosis was collected from the patient case report form. EDSS: Expanded Disability Status Scale; RRMS: relapsing-remitting multiple sclerosis; SPMS: secondary progressive multiple sclerosis.
bEDSS=0 (n=1); EDSS=1 (n=0); EDSS=1.5 (n=1).
cLiterature suggests that there are circumstances in which onset of progression to SPMS is early and identifiable at a DSS score of 2 or less [2].
dMinimum value of 0 indicates a duration of less than 12 months.