Table 1.

Patient demographics and clinical characteristics by physician diagnosis (N=198).^a

Patient characteristic		Physician diagnosis
		RRMS (n=89)	Transitioning (n=47)	SPMS (n=62)
Age (years)
	n	89	47	62
	Mean (SD)	38.1 (11.3)	46.2 (10.7)	53.4 (10.7)
	Median (range)	37 (19-66)	47 (28-68)	52 (34-78)
EDSS score
	n	81	47	61
	Mean (SD)	2.6 (1.0)	4.3 (1.1)	5.6 (1.4)
	Median (range)	2 (0-7)b,c	4 (2-7)	6 (3-9)
Patients with relapses in the past 6 months, n
	Yes	30	10	9
	No	59	37	53
Duration since RRMS diagnosis (years)
	n	89	47	62
	Mean (SD)	7.3 (6.3)	13.2 (8.4)	17.3 (10.1)
	Median (range)d	5.0 (0-26)	11.3 (0-37)	15.8 (0-51)
Duration since SPMS diagnosis (years)
	n	—	—	62
	Mean (SD)	—	—	6.3 (5.3)
	Median (range)d	—	—	5 (0-22)

^aPhysician diagnosis was collected from the patient case report form. EDSS: Expanded Disability Status Scale; RRMS: relapsing-remitting multiple sclerosis; SPMS: secondary progressive multiple sclerosis.

^bEDSS=0 (n=1); EDSS=1 (n=0); EDSS=1.5 (n=1).

^cLiterature suggests that there are circumstances in which onset of progression to SPMS is early and identifiable at a DSS score of 2 or less [2].

^dMinimum value of 0 indicates a duration of less than 12 months.