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. 2020 Mar 4;15(3):e0229344. doi: 10.1371/journal.pone.0229344

Table 2. Relative frequency of CKD evolution per stage of users and non-users of omeprazole followed-up at the nephrology ambulatory clinic of the Municipal Polyclinic of Divinópolis-MG, Brazil, 2016–2017 (n = 199).

CKD evolution General (n = 199) Non-omeprazole users (n = 114) Omeprazole users (n = 85) p-value
Total 36.2% 10.5% 70.6% < 0.0001*
Stage 2 → Stage 3a 2.4% 0.0% 5.5%
Stage 3a → Stage 3b 16.9% 7.6% 29.5%
Stage 3b → Stage 4 12.9% 2.9% 26.4%
Stage 4 → Stage 5 ND 3.9% 0.0% 9.2%
Stage 5 ND → Stage 5 D 0.0% 0.0% 0.0%

* Two-tailed Pearson chi-square test; CKD: Chronic kidney disease; ND: Non-dialytic.; D: Dialytic.