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. 2020 Mar 4;15(3):e0229621. doi: 10.1371/journal.pone.0229621

Fig 2. Time trends in proportions using various baseline glucose-lowering drug regimens at the time of initiation of DPP-4i, GLP-1RA, and SGLT2i, respectively.

Fig 2

Graphs show the proportion of patients who–at the time of their first initiation of either DPP-4i, GLP-1RA, or SGLT2i –are on no other GLD treatment (red graph), on another GLD monotherapy (green graph), on dual GLD therapy (blue graph), or on triple GLD therapy (purple graph). DPP-4i: dipeptidyl peptidase-4 inhibitor; GLP-1RA: glucagon-like peptide-1 receptor agonists; SGLT2i: sodium-glucose cotransporter 2 inhibitors; TECOS: Sitagliptin (DPP-4i) showed non-inferiority to placebo [35]; Lira obesity label: Liraglutide 3 mg launched as treatment for obesity; EMPA-REG OUTCOME: empagliflozin showed CV and CV/all-cause mortality benefits [10], LEADER: liraglutide showed CV and CV/all-cause mortality benefits [12]; CANVAS: canagliflozin showed CV benefits [11].