Table 1.

Comparison of mechanical parameters from myofibrils isolated from inherited cardiomyopathy models. RT: resting tension; ex-HcTnI: ex vivo myofibrils exchanged with human cardiac troponin complex; ex-RcTnI: ex vivo myofibrils exchanged with exogenous rat cardiac troponin complex; Δ: uncoupled from PKA regulation; * - (red): non-significant increase; * - (blue): non-significantly increase.

HCM
Gene	Mutation	Subject	RT	Ca2+ Sensitivity	F MAX	k ACT	k TR	Slow kREL	Slow tREL	Fast kREL	Refs
MYH7	R403Q	Human	-		↓	↑	↑	↑	↓	↑	Belus et al., 2008
TNNI3	R145G	ex-HcTnI / Tg mouse		↓	-	↓	↓	↓	↑	↓	Krüger et al., 2005
TNNI3	R145G	ex-RcTnI		↑	-	*-	-	↓	↑	-	Cheng et al., 2015
TNNI3	R21G	ex-RcTnI		↑	-	-	-	↓	↑	-	Cheng et al., 2015
TNNI3	P82S	ex-RcTnI		-	-	-Δ	-	-Δ	-	-	Cheng et al., 2016
TNNI3	K183del	Tg mouse		↓	↑	-	-	↓	↑	↓	lorga et al., 2008
TNNT2	R93Q	Tg mouse	-	↑	-	-	-	-	-	-	Ferrantini et al., 2017
TNNT2	E163R	Tg mouse	↑	↑	-	↑	↑	↑	↑	↓	Ferrantini et al., 2017
TNNT2	K280N	Human tissue	↑		-	↑	↑	↑	-	-	Piroddi et al., 2019
TPM1	D175N	ex-HcTnI		↑							Janco et al., 2012
TPM1	E180G	ex-HcTnI		↑							Janco et al., 2012
ACTC1	E99K	Human tissue		↑	-	-	-	↓	↑	↓	Song et al., 2013
DCM
Gene	Mutation	Subject	RT	Ca2+ Sensitivity	F MAX	k ACT	k TR	Slow kREL	Slow tREL	Fast k REL	Refs
TTN	R23464Tfs	Human	↓		-	-	-	-	-	-	Vikhorev et al., 2017
TTN	R23464Tfs	Human	↓		-	-	-	-	-	-	Vikhorev et al., 2017
TTN	Y18923	Human	↓		-	-	-	-	-	-	Vikhorev et al., 2017
MYH7	E1426K	Human	↓		-	-	-	-	↓	↑	Vikhorev et al., 2017
TNNI3	K36Q	Human	↓		-	-	-	-	↓	↑	Vikhorev et al., 2017
TNNC1	G159D	Human	↓		-	-	-	-	↓	*-	Vikhorev et al., 2017
ACTC1	E361G	Tg mouse		↑	-	-	-		↑	↓	Vikhorev et al., 2014
Un-identified	-	Dog	-	↓	↓	-	↑	↑	-	-	Cheng et al., 2016
RCM
Gene	Mutation	Subject	RT	Ca2+ Sensitivity	F MAX	k ACT	k TR	Slow kREL	Slow tREL	Fast k REL	Refs
TNNI3	R145W	ex-HcTnI		↑	↑	-	-	-Δ	-Δ	-	Dvornikov et al., 2016
Un-identified	-	Human	↑		-	-	-	↓	↑	↓	Jeong et al., 2018