Table 1. Characteristics of combination statin and AHT users in 2009–2014 Medicare claims data.
| RAS + any statin | Non-RAS AHT + any statin | ACEI + ator | ACEI + pra | ACEI + rosu | ACEI + sim | ARB + ator | ARB + pra | ARB + rosu | ARB + sim | |
|---|---|---|---|---|---|---|---|---|---|---|
| ADRD | 2.07% | 2.64% | 2.18% | 2.03% | 1.63% | 2.16% | 2.02% | 1.94% | 1.62% | 2.02% |
| Age | 77.3 | 78.0 | 77.2 | 77.2 | 76.2 | 77.1 | 77.6 | 77.8 | 76.7 | 77.6 |
| Female | 61% | 63% | 56% | 60% | 56% | 57% | 66% | 70% | 67% | 68% |
| White | 83% | 86% | 84% | 86% | 84% | 85% | 78% | 82% | 78% | 79% |
| Black | 6% | 6% | 6% | 7% | 7% | 6% | 7% | 7% | 6% | 7% |
| Hispanic | 6% | 4% | 6% | 4% | 6% | 5% | 7% | 5% | 8% | 7% |
| Other race | 5% | 4% | 4% | 3% | 3% | 3% | 9% | 6% | 8% | 7% |
| % HS grad | 76% | 76% | 76% | 75% | 75% | 76% | 76% | 76% | 75% | 76% |
| Median income | $55,745 | $55,919 | $56,728 | $53,436 | $54,187 | $54,208 | $59,299 | $55,548 | $56,784 | $56,319 |
| # physician visits | 9.5 | 9.9 | 9.1 | 9.2 | 9.9 | 8.7 | 10.7 | 10.8 | 11.6 | 10.1 |
| HCC | 1.25 | 1.33 | 1.26 | 1.24 | 1.25 | 1.24 | 1.28 | 1.26 | 1.26 | 1.26 |
| AMI | 9% | 9% | 10% | 8% | 10% | 9% | 8% | 7% | 8% | 7% |
| ATF | 18% | 23% | 18% | 19% | 18% | 17% | 18% | 19% | 17% | 17% |
| Diabetes | 53% | 40% | 52% | 51% | 54% | 53% | 55% | 52% | 57% | 54% |
| Stroke | 16% | 18% | 16% | 17% | 16% | 16% | 17% | 17% | 17% | 16% |
| Beneficiaries | 507,304 | 279,398 | 92,551 | 48,545 | 35,128 | 173,653 | 60,569 | 29,250 | 27,259 | 95,007 |
| Observations | 1,387,009 | 630,777 | 214,734 | 106,203 | 78,620 | 435,902 | 140,609 | 62,749 | 61,080 | 231,174 |
Sample of 2009–2014 Medicare person-years with 90 possession days and 2 claims of both an AHT and a statin in both years t-1 and t-2. RAS (renin-angiotensin system) AHTs are antihypertensive (AHT) prescription drugs (angiotensin converting enzyme inhibitors (ACEIs) and angiotensin-II receptor blockers (ARBs). Non-RAS acting AHTs are beta-blockers, calcium channel blockers, loop diuretics, and thiazide diuretics. Statins are atorvastatin, pravastatin, rosuvastatin, and simvastatin. Sample restricted to person-years with 3 years fee-for-service, 3 years Part D, age 67+, no deaths in the reference year (year t), no prior ADRD diagnoses, and no prior use of acetylcholinesterase inhibitors (AChEIs) or memantine. Abbrevations: ADRD (Alzheimer's disease and related dementias), HS (high school), HCC (Hierarchical Condition Category index), AMI (acute myocardial infarction), ATF (atrial fibrillation).