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. Author manuscript; available in PMC: 2020 Jun 22.
Published in final edited form as: Reprod Toxicol. 2019 May 15;92:129–137. doi: 10.1016/j.reprotox.2019.05.059

Figure 2.

Figure 2.

Metabolome-wide association study (MWAS) of serum p,p’-DDT (A), o,p’-DDT (B) and p,p’-DDE (C) concentrations in 397 subjects from the Child Health and Development Studies (CHDS) cohort. The extracted data was pre-filtered to retain 3121 features with non-zero values in > 80% in all samples and >50% in each group. Results shows that p,p’-DDE exposure was associated with more metabolic alterations than the parent chemicals (indicated by the raw P value and FDR adjusted Q value cutoff). Type 1 Manhattan plot for –log P vs m/z features and type 2 Manhattan plot for –log P vs retention time with C18 chromatography separation are presented left and right, respectively. Red indicates positive correlation between significant features (P < 0.05) and DDT exposure and blue indicates negative correlation.