Table 1. Sensitivity analysis variables to assess deviations from the initial model predictions.

Variable	Range	Name: definition
ϕ	[1, 103]	potency reduction factor: fold-reduction in concentration and/or fold-increase in in vivo IC50
f	[0, 1]	resistant fraction: fraction of circulating isolates with IC50>50 μg/mL
A0	[1, 20]	founder cells: the initial number of infected cells
x50	[50, 104]	maximum IC50: the true maximum IC50 for resistant variants (replaces the detection threshold 50 μg/mL)