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. Author manuscript; available in PMC: 2020 Mar 4.
Published in final edited form as: Lancet Oncol. 2019 May 28;20(7):915–923. doi: 10.1016/S1470-2045(19)30308-0

Figure 1: Analytical structure.

Figure 1:

The model inputs box displays the three models in dark blue that served as the core inputs for the GTFRCC radiotherapy investment framework: demand, costing, and survival. The demand and survival models were based on the work of the CCORE, and the costing model was developed in collaboration with the International Atomic Energy Agency. The light blue HPV vaccine scale-up model box identifies how the Papillomavirus Rapid Interface for Modelling and Economics model best case parameters were integrated into the GTFRCC model input structure by modulating the demand model. The dotted lines around the demand and survival boxes represent the model inputs that were varied in our sensitivity analysis on the population distribution of cervical cancer stage at diagnosis. The model outputs included the life years saved and return on investment (human capital and full income net present value). CCORE=Collaboration for Cancer Outcomes Research and Evaluation. GTFRCC=Global Task Force on Radiotherapy for Cancer Control. HPV=human papillomavirus.