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. Author manuscript; available in PMC: 2020 Mar 4.
Published in final edited form as: Lancet Oncol. 2019 May 28;20(7):915–923. doi: 10.1016/S1470-2045(19)30308-0

Table 3:

Population health and economic effects of scaling up radiotherapy capacity for cervical cancer treatment, 2015–35

Health parameters
Human capital return on investment
Full income return on investment
Patients requiring external-beam radiotherapy Patients requiring brachytherapy Life-years gained with radiotherapy scale-up Nominal model Efficient model Nominal model Efficient model
Base case values
Low-income countries 1 340 413 1 005 310   2 348 608 −0·4   0·3   0·3   1·8
Lower-middle-income countries 4 892 966 3 669 725   6 188 537   1·6   4·2   4·3   9·7
Upper-middle-income countries 3 120 872 2 340 654   2 861 813   6·1 12·3 14·2 27·7
Total 9 354 251 7 015 689 11 398 958   2·5   6·0   6·5 13·8

Sensitivity analysis: advanced stage distribution
Low-income countries 1 623 599 1 282 643   3 359 445   0·0   1·1   1·1   3·3
Lower-middle-income countries 5 926 692 4 682 086   9 655 660   3·0   7·0   7·2 15·4
Upper-middle-income countries 3 780 211 2 986 367   4 480 428   8·7 17·3 20·0 38·6
Total 11 330 502 8 951 096 17 495 533   4·0   9·5   9·9 22·1

Sensitivity analysis: integrated radiotherapy and vaccination scale-up
Low-income countries 1 284 243    963 183   2 041 140 −0·4 −0·1   0·3   0·9
Lower-middle-income countries 4 729 919 3 547 440   5 936 526   1·1   3·2   3·2   7·5
Upper-middle-income countries 3 014 362 2 260 772   2 694 691   5·6 11·4 13·4 25·87
Total 9 028 525 6 771 394 10 672 357   2·2   5·1   5·6 11·7

Return on investment is a ratio defined as the net present value (itself defined as the economic return on investment minus the cost of investment) divided by the cost of investment, all in US$.