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. 2020 Jan 15;11(1):e00112. doi: 10.14309/ctg.0000000000000112

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© 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 1. — Expression of miRNA-346, TNF-α, VDR, and p27 ^kip1 in the ascending colon. In patients with PSC-UC, the expression of miRNA-346 (a) was increased, whereas the levels of VDR protein (c) and TNF-α protein (d) were not changed in comparison to controls. The expression cell cycle inhibitor p27 ^kip1 (e) was substantially inhibited both in patients with PSC-UC and PSC. In contrast, in patients with UC, the miRNA-346 expression (a) was drastically suppressed, and it was accompanied by the enhanced expression of TNF-α mRNA (b), VDR protein (c), and TNF-α protein (d), whereas the expression cell cycle inhibitor p27 ^kip1 (e) was comparable to control values. MicroRNA-191 served as reference microRNA. Results are representative of n = 10 independent experiments per group. Data are presented as median plus IQR. IQR, interquartile range; VDR, receptor of vitamin D.