Table 1. Known myelin proteins in the myelin proteome.
Proteins mass-spectrometrically identified in peripheral myelin are compiled according to availability of prior references as myelin proteins. Given are the official gene name, one selected reference, the number of transmembrane domains (TMD) and the mRNA abundance profile cluster (see Figure 3).
| Protein name | Gene | Reference | TMD | Cluster |
|---|---|---|---|---|
| 2-hydroxyacylsphingosine 1-beta-galactosyltransferase | Ugt8 | Bosio et al., 1996 | 2 | P6-up |
| Syntrophin α1 | Snta1 | Fuhrmann-Stroissnigg et al., 2012 | - | P18-up |
| Annexin A2 | Anxa2 | Hayashi et al., 2007 | - | Descending |
| Band 4.1 protein B/4.1B | Epb41l3 | Ivanovic et al., 2012 | - | Descending |
| Band 4.1 protein G/4.1G | Epb41l2 | Ohno et al., 2006 | - | P6-up |
| Breast carcinoma-amplified sequence 1 | Bcas1 | Ishimoto et al., 2017 | - | P6-up |
| Cadherin 1/E-Cadherin | Cdh1 | Fannon et al., 1995 | 1 | P18-up |
| Carbonic anhydrase 2 | Ca2 | Cammer and Tansey, 1987 | - | Descending |
| Catenin α1 | Ctnna1 | Murata et al., 2006 | - | U-shaped |
| Catenin ß1 | Ctnnb1 | Fannon et al., 1995 | - | Descending |
| Caveolin 1 | Cav1 | Mikol et al., 2002 | 1 | P18-up |
| CD9, tetraspanin 29 | Cd9 | Ishibashi et al., 2004 | 4 | P18-p |
| CD59A | Cd59a | Funabashi et al., 1994 | 1 | P18-up |
| CD47, integrin-associated signal transducer | Cd47 | Gitik et al., 2011 | 5 | P6-up |
| CD81, tetraspanin 28 | Cd81 | Ishibashi et al., 2004 | 4 | P18-up |
| CD82, tetraspanin 27 | Cd82 | Chernousov et al., 2013 | 4 | P18-up |
| CD151, tetraspanin 24 | Cd151 | Patzig et al., 2011 | 4 | P18-up |
| Cell adhesion molecule 4/NECL4 | Cadm4 | Spiegel et al., 2007 | 1 | P6-up |
| Cell division control protein 42 | Cdc42 | Benninger et al., 2007 | - | P6-up |
| Cell surface glycoprotein MUC18 | Mcam | Shih et al., 1998 | 1 | Descending |
| Ciliary neurotrophic factor | Cntf | Rende et al., 1992 | - | Late-up |
| CKLF-like MARVEL TMD-containing 5 | Cmtm5 | Patzig et al., 2011 | 4 | P6-up |
| Claudin-19 | Cldn19 | Miyamoto et al., 2005 | 4 | P6-up |
| Cofilin 1 | Cfl1 | Sparrow et al., 2012 | - | Descending |
| Crystallin α2 | Cryab | D'Antonio et al., 2006 | - | P18-up |
| Cyclic nucleotide phosphodiesterase | Cnp | Matthieu et al., 1980 | - | P6-up |
| Sarcoglycan δ | Sgcd | Cai et al., 2007 | 1 | Late-up |
| Dihydropyrimidinase related protein 1 | Crmp1 | D'Antonio et al., 2006 | - | Descending |
| Disks large homolog 1 | Dlg1 | Cotter et al., 2010 | - | Descending |
| Dynein light chain 1 | Dynll1 | Myllykoski et al., 2018 | - | P6-up |
| Dystroglycan | Dag1 | Yamada et al., 1994 | 1 | P6-up |
| Dystrophin/DP116 | Dmd | Cai et al., 2007 | - | P6-up |
| Dystrophin-related protein 2 | Drp2 | Sherman et al., 2001 | - | P18-up |
| E3 ubiquitin-protein ligase NEDD4 | Nedd4 | Liu et al., 2009 | - | Descending |
| Ezrin | Ezr | Scherer et al., 2001 | - | P6-up |
| Fatty acid synthase | Fasn | Salles et al., 2002 | - | P6-up |
| Flotillin 1 | Flot1 | Lee et al., 2014 | - | P18-up |
| Gap junction ß1 protein/Cx32 | Gjb1 | Li et al., 2002 | 4 | P18-up |
| Gap junction γ3 protein/Cx29 | Gjc3 | Li et al., 2002 | 1 | P6-up |
| Gelsolin | Gsn | Gonçalves et al., 2010 | - | Late-up |
| Glycogen synthase kinase 3ß | Gsk3b | Ogata et al., 2004 | - | P6-up |
| Integrin α6 | Itga6 | Nodari et al., 2008 | 1 | P6-up |
| Integrin αV | Itgav | Chernousov and Carey, 2003 | 1 | Descending |
| Integrin ß1 | Itgb1 | Feltri et al., 2002 | 1 | Descending |
| Integrin ß4 | Itgb4 | Quattrini et al., 1996 | 2 | P18-up |
| Junctional adhesion molecule C | Jam3 | Scheiermann et al., 2007 | 1 | P18-up |
| Laminin α2 | Lama2 | Yang et al., 2005 | - | P6-up |
| Laminin α4 | Lama4 | Yang et al., 2005 | - | Descending |
| Laminin ß1 | Lamb1 | LeBeau et al., 1994 | - | Descending |
| Laminin ß2 | Lamb2 | LeBeau et al., 1994 | - | P18-up |
| Laminin γ1 | Lamc1 | Chen and Strickland, 2003 | - | Descending |
| Membrane Palmitoylated Protein 6 | Mpp6 | Saitoh et al., 2019 | - | P6-up |
| Microtubule-associated protein 1A | Map1a | Fuhrmann-Stroissnigg et al., 2012 | - | P18-up |
| Microtubule-associated protein 1B | Map1b | Fuhrmann-Stroissnigg et al., 2012 | - | P6-up |
| Mitogen-activated protein kinase 1/ERK2 | Mapk1 | Mantuano et al., 2015 | - | Descending |
| Mitogen-activated protein kinase 3/ERK1 | Mapk3 | Mantuano et al., 2015 | - | P18-up |
| Moesin | Msn | Scherer et al., 2001 | - | Unchanged |
| Monocarboxylate transporter 1 | Slc16a1 | Domènech-Estévez et al., 2015 | 11 | P18-up |
| Myelin associated glycoprotein | Mag | Figlewicz et al., 1981 | 1 | P6-up |
| Myelin basic protein | Mbp | Boggs, 2006 | - | P6-up |
| Myelin protein 2 | Pmp2 | Trapp et al., 1984 | - | P18-up |
| Myelin protein zero/P0 | Mpz | Giese et al., 1992 | 1 | P6-up |
| Myelin proteolipid protein | Plp1 | Garbern et al., 1997 | 4 | P6-up |
| Myotubularin-related protein 2 | Mtmr2 | Bolino et al., 2004 | - | P6-up |
| Noncompact myelin-associated protein | Ncmap | Ryu et al., 2008 | 1 | P18-up |
| NDRG1, N-myc downstream regulated | Ndrg1 | Berger et al., 2004 | - | P18-uP |
| Neurofascin | Nfasc | Tait et al., 2000 | 2 | P18-up |
| Nidogen 1 | Nid1 | Lee et al., 2007 | - | Descending |
| P2X purinoceptor 7 | P2r×7 | Faroni et al., 2014 | - | P6-up |
| Paxillin | Pxn | Fernandez-Valle et al., 2002 | - | P6-up |
| Periaxin | Prx | Gillespie et al., 1994 | - | P6-up |
| Plasmolipin | Pllp | Bosse et al., 2003 | 4 | P18-up |
| Profilin 1 | Pfn1 | Montani et al., 2014 | - | Descending |
| Lin-7 homolog C | Lin7c | Saitoh et al., 2017 | - | P6-up |
| Rac1 | Rac1 | Benninger et al., 2007 | - | U-Shaped |
| Radixin | Rdx | Scherer et al., 2001 | - | Descending |
| RhoA | Rhoa | Brancolini et al., 1999 | - | U-Shaped |
| Septin 2 | Sept2 | Buser et al., 2009 | - | Descending |
| Septin 7 | Sept7 | Buser et al., 2009 | - | U-Shaped |
| Septin 8 | Sept8 | Patzig et al., 2011 | - | P18-up |
| Septin 9 | Sept9 | Patzig et al., 2011 | - | P6-up |
| Septin 11 | Sept11 | Buser et al., 2009 | - | Descending |
| Sirtuin 2, NAD-dependent deacetylase | Sirt2 | Werner et al., 2007 | - | P18-up |
| Spectrin alpha chain, non-erythrocytic 1 | Sptan1 | Susuki et al., 2018 | - | P18-up |
| Spectrin beta chain, non-erythrocytic 1 | Sptbn1 | Susuki et al., 2018 | - | P18-up |
| Tight junction protein ZO-1 | Tjp1 | Poliak et al., 2002 | - | P6-up |
| Tight junction protein ZO-2 | Tjp2 | Poliak et al., 2002 | - | P6-up |
| Transferrin | Tf | Lin et al., 1990 | 2 | Late-up |
| Vimentin | Vim | Triolo et al., 2012 | - | Unchanged |
| Vinculin | Vcl | Beppu et al., 2015 | - | Descending |