Figure 5. Stxbp1 haploinsufficient mice show increased aggressive behaviors and reduced nest building and digging behaviors.
(A–C) In the resident-intruder test, male Stxbp1tm1d/+ and Stxbp1tm1a/+ mice showed a reduction in the latency to attack the male intruder mice (A). The total duration (B) and number (C) of their attacks were increased as compared to WT mice. (D) In the tube test, Stxbp1tm1d/+ and Stxbp1tm1a/+ mice won more competitions against their WT littermates. (E) In the three-chamber test, Stxbp1tm1d/+ and Stxbp1tm1a/+ mice showed a preference in interacting with the partner mouse over the object. (F,G) Stxbp1tm1d/+ and Stxbp1tm1a/+ mice built poor quality nests. The quality of the nests was scored according to the criteria in (F) for three consecutive days (G). (H) Stxbp1tm1d/+ and Stxbp1tm1a/+ mice buried fewer marbles than WT mice. The numbers and ages of tested mice are indicated in the figures. Each filled (male) or open (female) circle represents one mouse. Bar graphs are mean ± s.e.m. *, p<0.05; **, p<0.01; ***, p<0.001; ****, p<0.0001.
Figure 5—figure supplement 1. Stxbp1 haploinsufficient mice show normal social interactions.
