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. 2020 Mar 4;6(10):eaaz0525. doi: 10.1126/sciadv.aaz0525

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Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 5 — Five million offspring were generated from crosses between drive/wild-type heterozygotes and wild-type individuals for each number of gRNAs and each level of probability that incomplete homology-directed repair results in the formation of resistance alleles that preserve the function of the target gene. The formation rate of resistance alleles that preserve the function of the target gene is shown. No such resistance alleles were formed in systems with at least four gRNAs, except in drives where incomplete homology-directed repair was possible.