Fig. 1. Schematic diagram of the designed strategy for the combined therapy of CHT by MTH1 inhibitor and PDT by Ce6.

In the combined therapy, the scavenger of 8-oxo-dG is inhibited by TH588, and thus, the oxidation-induced DNA mutant can be amplified. The mutant can be found in both nDNA and mtDNA, leading to the apoptosis of the cancer cells.