Figure 2.
Meta-analysis of 76 preclinical studies shows therapeutic potential for targeting mitochondrial pathways in ALS. Forest plot showing the odds ratio and confidence intervals calculated from survival summary data from each study, weighted by study size. Overall effect estimate is demonstrated (with 95% confidence intervals) as a black diamond at the bottom of the graph. Heterogeneity is displayed as an I2 value. Results demonstrate an overall statistically significant effect favouring targeting of mitochondrial pathways in ALS.