Table 2.

Mutation pattern of drug resistance for multidrug therapy

Sl.No	Drugs	Leprosy type	Mutation	Position	Change in nucleotide
1	Rifampicin and ofloxacin	BT	Leu436Gln and Ala91Pro	279 bp (2275228–2275506) 2275524, 225 bp (7499–7682)	CTG → CAG (T is replaced by A) GCA → CCA (G is replaced by C)
2	Dapsone and ofloxacin	BT	Pro55Leu and Ala91Val	254 bp (296800–297025) 296859, 225 bp (7499–7682)	CCC → CTC (C is replaced by T) GCA → GTA (C is replaced by T)
3	Dapsone	BT	Pro55Ser	254 bp (296800–297025) 296859	CCC → TCC (C is replaced by T)
4	Ofloxacin	BT	Gly89Ala	225 bp (7499–7682)	GGC → GCC (G is replaced by C)
5	Ofloxacin	BT	Gly89Cys	225 bp (7499–7682)	GGC → TGC (G is replaced by T)
6	Ofloxacin	BL	Ala91Pro	225 bp (7499–7682)	GCA → GTA (C is replaced by T)

BT = borderline tuberculoid. Bold indicates position of mutation and change in nucleotide.