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. 2020 Mar 4;40(3):BSR20194188. doi: 10.1042/BSR20194188

Figure 2. ALK5 knockdown inhibits macrophage activation.

Figure 2

(A) Western blot analysis of ALK5 level in BMDMs transfected with AdshALK5 or AdshSCR upon OX-LDL (50 ng/ml) treatment; n = 3. (B) Attenuated M1 markers but enhanced M2 markers gene expression in BMDMs infected with AdshALK5 or AdshSCR induced by OX-LDL; n = 3. (C) Foam cell formation of macrophages transfected with AdshALK5 or AdshSCR induced by OX-LDL; scale bar = 25 μm; n = 9. (D) RT-PCR analysis of Cd36, Sra, Abca1 and Abcg1 expression in BMDMs transfected with AdshALK5 or AdshSCR upon OX-LDL administration; n = 3. *P < 0.05 compared with control group.