Figure 3.

Common endothelial benefits induced by laminar shear stress and resveratrol. Both shear stress and resveratrol trigger SIRT1 up‐regulation, ROS level down‐regulation, inhibition of monocyte recruitment, increased autophagy, endothelial elongation, and improved re‐endothelialization in endothelial cells. Similar elongation patterns are observed in phase contrast images of laminar flow‐treated (reproduced with permission; Copyright 2017, Development; Poduri et al., 2017) and resveratrol‐treated endothelial cells (reproduced with permission; Copyright 2011, Journal of Atherosclerosis and Thrombosis; Cicha et al., 2011)