Fig. 1.

Prevalence of DNA damage repair pathways. A. Homologous recombination deficiency was measured as in Marquard et al. [11] (HRD Score) and shows that MOC rarely have a score above that used to predict response to platinum or PARP inhibitors (BRCA-deficient median and blue zone indicating HRD Score >42 that may respond to platinum from Telli et al. [13]). Black diamond is the mean HRD Score. B. Mismatch repair deficiency is also rare, as indicated by the mutation burden: Mutations per Mb, log10 transformed, black diamond is the mean, dashed line is a suggested threshold for mismatch-repair deficiency detection from Nowak et al. [14]. Arrow, MOC with MSH6 mutation, arrowheads, extra-ovarian metastases (EOM) with MMR gene mutations, *, MOC with MSH6 mutation that is likely non-pathogenic. BEN, benign mucinous tumor, MBT, mucinous borderline tumor. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)