Table 2:
Instability of [18F]FTHA at different radioactivity concentration and growth of unknown side product over time.
| SN | Fatty acid | Radioactivity Concentration (GBq/mL or mCi/mL) | Time of Post synthesis analysis | Peak I (Unknown) | Peak II (Product) | |||
|---|---|---|---|---|---|---|---|---|
| Retention Time (min) | Relative Percentage | Retention Time | Relative Percentage | |||||
| 1 | [18F]FTHA | High conc. (2.37 GBq/mL or 64.0 mCi/mL at time zero) | 2.2 GBq/mL (60.1 mCi/mL) | 10 min | 4.08 | 10.2% | 6.38 | 89.8% |
| 1.6 GBq/mL (43.8 mCi/mL) | 60 min | - | - | - | - | |||
| 1.1 GBq/mL (30.0 mCi/mL) | 120 min | 4.08 | 28.3% | 6.33 | 71.7% | |||
| 0.76 GBq/mL (20.5 mCi/mL) | 180 min | 4.07 | 34.3% | 6.34 | 65.7% | |||
| 0.52 GBq/mL (14.0 mCi/mL) | 240 min | 4.11 | 37.2% | 6.76 | 62.8% | |||
| Low conc. (0.89 GBq/mL or 24.0 mCi/mL at time zero) | 0.74 GBq/mL (19.9 mCi/mL) | 30 min | 4.22 | 11.5% | 6.41 | 88.5% | ||
| 0.60 GBq/mL (16.4 mCi/mL) | 60 min | 4.04 | 10.0% | 6.35 | 90.0% | |||
| 0.41 GBq/mL (11.2 mCi/mL) | 120 min | 4.02 | 14.2% | 6.20 | 85.8% | |||
| 0.29 GBq/mL (7.7 mCi/mL) | 180 min | 4.08 | 13.8% | 6.34 | 86.2% | |||
| 0.20 GBq/mL (5.27 mCi/mL) | 240 min | 4.16 | 13.3% | 6.79 | 86.7% | |||
| 2 | [18F]FTHA | High conc. (1.25 GBq/mL or 33.9 mCi/mL at time zero) | 1.2 GBq/mL (31.8 mCi/mL) | 10 min | 4.05 | 6.0% | 6.15 | 94.0% |
| 0.86 GBq/mL (23.2 mCi/mL) | 60 min | 4.05 | 9.1% | 6.12 | 90.9% | |||
| 0.59 GBq/mL (15.9 mCi/mL) | 120 min | 4.08 | 9.4% | 6.12 | 90.6% | |||
| 0.40 GBq/mL (10.9 mCi/mL) | 180 min | 4.13 | 11.9% | 6.20 | 88.1% | |||
| 0.28 GBq/mL (7.5 mCi/mL) | 240 min | 4.03 | 12.8% | 6.14 | 87.2% | |||
| Low conc. (0.52 GBq/mL or 14.0 mCi/mL at time zero) | 0.43 GBq/mL (11.6 mCi/mL) | 30 min | 3.57 | 5.4% | 5.62 | 94.6% | ||
| 0.36 GBq/mL or 9.6 mCi/mL | 60 min | 4.05 | 8.8% | 6.14 | 91.2% | |||
| 0.24 GBq/mL (6.5 mCi/mL) | 120 min | 4.03 | 8.3% | 6.18 | 91.7% | |||
| 0.17 GBq/mL (4.5 mCi/mL) | 180 min | - | - | - | - | |||
| 0.11 GBq/mL (3.0 mCi/mL) | 240 min | 4.09 | 9.8% | 6.12 | 90.2% | |||