Table 1:
Baseline Demographic and Clinical Characteristics
| NAFLD (n=43) | Healthy (n=11) | P value | |
|---|---|---|---|
| Age (years) | 54 (42–59) | 33 (25–40) | <0.0001 |
| Male Sex (n, %) | 22 (55%) | 5 (45%) | 0.5 |
| Race (%) | 0.72 | ||
| Non-white | 26 (60%) | 6 (55%) | |
| White | 17 (40%) | 5 (45%) | |
| Hispanic ethnicity | 19 (44%) | 0 | |
| BMI (kg/m2) | 32.2 (28.5–35.3) | 21.8 (21–22.8) | <0.0001 |
| ALT (U/L) | 27 (28–64) | 16 (17–23) | <0.0001 |
| AST (U/L) | 28 (21–49) | 19 (13–19) | 0.001 |
| Platelets (K/uL) | 238 (206–250) | 221 (206–234) | 0.29 |
| Insulin (μU/mL) [n=42] | 23.8 (16.4–30.5) | 9 (5.1–10.1) | <0.0001 |
| Glucose (mg/dL) | 102 (83–162) | 88 (83–94) | 0.0003 |
| HOMA-IR [n=42] | 5.85 (4.2–7.9) | 1.97 (1.06–2.32) | <0.0001 |
| Triglyceride (mg/dL) | 142 (109–186) | 54 (44–88) | <0.0001 |
| Diabetes (n, %) | 11 (26%) | 0 | |
| Liver fat content by 1H-MRS (%) [n=14] | 16.6 (28–68.5) | NA | |
| Liver Stiffness Measurement (kPa) [n=35] | 3.5 (4.5–7.9) | NA | |
| Liver biopsy [n=11] | |||
| Steatohepatitis | 6 (55%) | NA | |
| NAFLD activity score (NAS) | 3 (2–5) | NA |
Results are expressed as median (IQR) or number (percentage). NA – not applicable