Table 1.
Baseline Characteristics of Participants Aged 80 Years or Older
| Intensive treatment N = 586 | Standard treatment N = 581 | |
|---|---|---|
| Age | ||
| Mean (SD), y | 83.3 (3.0) | 83.7 (3.3) |
| >85 y, n (%) | 136 (23.2) | 154 (26.5) |
| >90 y, n (%) | 16 (2.7) | 22 (3.8) |
| Female sex, n (%) | 221 (37.7) | 231 (39.8) |
| Race/Ethnicity, n (%) | ||
| White | 442 (75.4) | 445 (76.6) |
| Black | 95 (16.2) | 93 (16.0) |
| Hispanic | 42 (7.2) | 38 (6.5) |
| Other | 7 (1.2) | 5 (.9) |
| Body mass index, mean (SD), kg/m2 | 27.1 (4.8) | 27.0 (4.6) |
| Seated blood pressure, mean (SD), mm Hg | ||
| Systolic | 142.2 (15.6) | 142.9 (16.6) |
| Diastolic | 70.0 (11.3) | 70.0 (11.2) |
| Orthostatic hypotension, n (%) | 55 (9.5) | 59 (10.2) |
| History of CVD, n (%) | 165 (28.2) | 152 (26.2) |
| Estimated GFRa | ||
| Mean (SD), mL/min/1.73 m2 | 60.9 (18.3) | 59.6 (17.8) |
| <60 mL/min/1.73 m2, n (%) | 288 (49.6) | 303 (52.5) |
| Urinary albumin to creatinine ratio, median (IQR), mg/g | 15.0 (8.0–39.4) | 16.1 (9.0–41.4) |
| No. of medications, mean (SD) | 6.6 (3.6) | 6.4 (3.6) |
| No. of antihypertensive agents, mean (SD) | 1.9 (1.0) | 1.9 (1.1) |
| Statin use, n (%) | 287 (49.7) | 305 (53.1) |
| Aspirin use, n (%) | 364 (62.3) | 339 (58.5) |
| Gait speed | ||
| Median (IQR), m/s | .86 (.72–1.00) | .87 (.73–1.02) |
| Speed <.8 m/s, n (%) | 204 (36.2) | 205 (36.8) |
| MoCA score, n (%)b | 22 (19–24) | 22 (19–24) |
| ≤18 (<HS)/≤20 (≥HS) | 208 (36.0) | 205 (35.5) |
| VR-12 PCS, mean (SD)c | 42.4(10.4) | 43.4 (9.7) |
| VR-12 MCS, mean (SD)c | 54.6 (8.2) | 54.9 (8.6) |
Abbreviations: CVD, cardiovascular disease; GFR, glomerular filtration rate; HS, high school education; IQR, interquartile range; MCS, Mental Component Summary; MoCA, Montreal Cognitive Assessment; PCS, Physical Component Summary; SD, standard deviation; VR-12, Veterans RAND 12-Item Health Survey.
a
Based on the four-variable Modification of Diet in Renal Disease equation.
b
Scores range from 0 to 30, with higher scores denoting better cognitive function.
c
Scores on the PCS and MCS of the VR-12 are standardized with a mean of 50 and an SD of 10; scores range from 0 to 100, with higher scores denoting better physical health and mental health, respectively.