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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Mol Cancer Ther. 2019 Dec 17;19(3):731–741. doi: 10.1158/1535-7163.MCT-19-0809

Figure 1. Identification of didesmethylrocaglamide and rocaglamide with potent growth-inhibitory activity comparable to silvestrol.

Figure 1.

The structure of each rocaglate is shown along with its IC50 value in STS26T MPNST cells as determined in Table 1. Structure-activity comparison revealed that the dioxanyl (dioxanyloxy) ring is dispensable but may enhance the cytotoxicity of rocaglates. An unmethylated C-8b hydroxyl group (arrow) and the amide functionality (rectangle) of didesmethylrocaglamide and rocaglamide are important for optimum antiproliferative activity, while methylation of the C-8b hydroxyl group (oval) substantially impaired the activity.