Figure 3. Unlike silvestrol, DDR and Roc inhibits proliferation of MDR1-overexpressing 697-R leukemic cells at IC₅₀ values similar to parental 697 cells.

Cell proliferation was measured on 697-R and 697 cells treated for 3 days with various concentrations of silvestrol (A), DDR (B), and Roc (C). Each treatment was performed in six replicates, and each experiment was repeated twice. Shown are representative dose-response growth inhibition curves for all three drugs from experiments run in parallel. The insets show the IC₅₀ values for each compound.