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. 2019 Dec 10;39(10):2212–2223. doi: 10.1038/s41388-019-1137-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Western blot analysis of each KPNA4 as well as KPNB1 in various HNSCC cell lines expressing shRNA for KPNA4. b Western blot analysis of GFP^NLS in both cytoplasmic and nucleus fraction. c Quantification of the protein levels were performed. Data show mean ± SD from three independent experiments (n = 3). One sample t test was performed using GraphPad QuickCalcs. *p < 0.05. d Short-term proliferation was analyzed MTT assay Data represent means ± SD (n = 3). e The heat map from microarray data showing upregulated and downregulated genes after knockdown of KPNA4. f GO analysis of the upregulated genes upon KPNA4 depletion. g Pathway analysis of the downregulated genes after KPNA4 knockdown.