Table 2.

Example interview questions

Example question	Concept mapping to 3D taxonomy
Reflecting on your diversity of experiences, can you walk me through the process of interpreting uncertain lab results pertaining to [variant disorder]?	Scientific issue: diagnostic aspects of uncertainty
From your perspective, what comparisons do you observe between how families react when their child is initially diagnosed with [variant disorder] versus [classic form of disorder]?	Personal issue: psychological aspects of uncertainty
How do you think [variant disorder] should be managed and how does this compare to clinically available practice guidelines, algorithms, and protocols?	Scientific issue: therapeutic aspects of uncertainty
What strategies would you recommend to other health-care providers if they have to communicate an uncertain result to a family in the context of [variant disorder]?	Personal issue: social aspects of uncertainty
Some might say that there is a lack of clear direction and consensus in managing [variant disorder]. How are local protocols or care plans developed at your institution for managing this disorder?	Practical issue: procedural aspects of uncertainty