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. 2020 Feb 27;7:5. doi: 10.3389/fnut.2020.00005

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Copyright © 2020 Miyano, Ohshima, Suzuki, Furuya, Yoshida, Nonaka, Higami, Yoshizawa, Fujii and Uezono.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of Ninjinyoeito (NYT) on impedance changes in cells expressing several G-protein-coupled receptors, which activate hyperphagia signaling in the central nervous system using the CellKey™ assay. The cells stably expressing growth hormone secretagogue receptor 1a (GHSR) (A, n = 6–8), neuropeptide Y1 receptor (NPY1R) (B, n = 6), neuropeptide Y5 receptor (NPY5R) (C, n = 6), or orexin 1 receptor (OX1R) (D, n = 6) were treated with NYT (3–100 μg/kg) or its vehicle (control). The rate of change in impedance was measured using the CellKey™ system and expressed as the difference of the minimum impedance and maximum impedance after drug injection. The data are expressed as mean ± S.E.M. *** and **** indicate p < 0.001 and p < 0.0001, respectively, compared with the control; Bonferroni's multiple comparison test following one-way ANOVA.