Table 3.
In vitro maturation and embryology outcomes
| Oocyte developmental outcomes | CAPA-IVM (N = 40) | Standard IVM (N = 40) | Between-group difference (95% CI)a | p valueb |
|---|---|---|---|---|
| Number of COCs | 17.5 [11.0, 23.0] | 16.5 [9.8, 21.0] | 1 (− 3, 7) | 0.39 |
| % Maturation (MII) | 63.6 [55.0, 75.0] | 49.0 [35.9, 62.1] | 14.6 (5.5, 24) | < 0.001 |
| % Pronuclear stage per ICSI | 84.0 [72.9, 100.0] | 84.50 [72.0, 100.0] | − 0.5 (− 10.7, 11.9) | 0.80 |
| % Grade 1 or 2 embryos per pronuclear stage | 37.5 [23.8, 50.0] | 35.40 [16.4, 50.0] | 2.1 (− 11.5, 14.6) | 0.60 |
| % Grade 1 or 2 embryos per metaphase II | 30.0 [13.9, 43.3] | 26.80 [14.3, 40.7] | 3.2 (− 8.6, 16.2) | 0.70 |
| % Grade 1 or 2 embryos per COC | 18.9 [8.5, 26.9] | 12.7 [7.3, 20.4] | 6.2 (− 1.5, 12.4) | 0.11 |
| No embryo, n (%) | 1 (25) | 1 (25) | – | – |
| Frozen embryos remaining after first ET, n | 2.5 ± 2.5 | 1.3 ± 1.9 | 0.02 |
Values are median [interquartile range], number of patients (%), mean ± standard deviation, or difference (95% confidence interval)
CAPA capacitation culture, CI confidence interval, COC cumulus-oocyte complex, EQ1 day 3 embryo quality grade 1, EQ2 day 3 embryo quality grade 2, ICSI intracytoplasmic sperm injection, IQR interquartile range, IVM in vitro maturation
aBootstrapping and resampling 1000 times
bWilcoxon rank sum test p value