Fig. 2.

Effect of ovariectomy and losartan on behavior in the elevated plus maze. EPM was assessed in Sham–Veh (n = 17), Ovx–Veh (n = 17), Sham–Los (n = 12), and Ovx–Los (n = 12) animal groups; a distance traveled during the EPM test. b Number of entries into the open arms; Ovariectomy reduced the number of entries into the open arms in Veh-treated rats; *p < 0.05 versus Sham, same treatment (Student’s t test). c Amount of time spent in the open arms; Ovariectomy reduced the amount of time spent in the open arms in Veh-treated rats; *p < 0.05 versus Sham, same treatment (Student’s t test)