Table 3.
Crude and adjusted hazard ratios for associations between determinants and all-cause mortality and cardiovascular disease incidence
| Variable | All-cause mortality | CVD incidence | ||
|---|---|---|---|---|
| Crude HR (95% CI) |
Adjusted HR (95% CI) |
Crude HR (95% CI) |
Adjusted HR (95% CI) |
|
| Age at start of RRTa | ||||
| 0–<2 | 2.41 (1.27–4.57) | 2.87 (1.42–5.82) | 0.73 (0.27–2.02) | 0.89 (0.31–2.59) |
| 2–<6 | 0.93 (0.60–1.44) | 1.39 (0.67–2.67) | 0.54 (0.23–1.25) | 0.77 (0.32–1.91) |
| 6–<12 | 0.97 (0.50–1.89) | 1.04 (0.66–1.64) | 0.67 (0.38–1.17) | 0.79 (0.44–1.41) |
| 12–18 | 1.00 | 1.00 | 1.00 | 1.00 |
| Sexb | ||||
| Males | 1.27 (0.89–1.82) | 1.31 (0.92–1.88) | 1.51 (0.96–2.38) | 1.76 (1.11–2.79) |
| Females | 1.00 | 1.00 | 1.00 | 1.00 |
| PRDc | ||||
| GN | 0.99 (0.61–1.65) | 1.01 (0.61–1.69) | 1.17 (0.63–2.18) | 1.12 (0.59–2.19) |
| Other | 1.45 (0.98–2.13) | 1.50 (1.01–2.22) | 1.46 (0.90–2.37) | 1.67 (1.01–2.75) |
| CAKUT | 1.00 | 1.00 | 1.00 | 1.00 |
| Initial RRT modalityd | ||||
| HD | 2.97 (1.08–8.07) | 2.57 (0.92–7.18) | 2.04 (0.86–4.78) | 1.73 (0.73–4.11) |
| PD | 2.41 (0.87–6.70) | 2.06 (0.73–5.85) | 1.17 (0.49–2.82) | 1.38 (0.56–3.41) |
| Pre-Tx | 1.00 | 1.00 | 1.00 | 1.00 |
| RRT modality during follow-upe | ||||
| HD + Tx- | 14.4 (8.01–25.77) | 20.03 (10.77–37.25) | 5.51 (2.14–14.16) | 6.20 (2.29–16.80) |
| PD + Tx- | 17.3 (9.71–30.76) | 20.69 (10.73–39.89) | 5.50 (2.41–12.55) | 5.81 (2.50–13.50) |
| Pre-Tx | 0.55 (0.20–1.51) | 0.68 (0.25–1.86) | 0.74 (0.32–1.71) | 0.69 (0.30–1.61) |
| D + Tx+ | 1.00 | 1.00 | 1.00 | 1.00 |
CVD cardiovascular disease; HR hazard ratio, CI confidence interval; RRT renal replacement therapy; PRD primary renal disease; GN glomerulonephritis, CAKUT congenital anomalies of kidney and urinary tract; HD haemodialysis; PD peritoneal dialysis; pre-Tx pre-emptively transplanted; HD + Tx started on HD and not transplanted during follow-up, PD + Tx started on PD and not transplanted during follow-up, D + Tx + transplanted ever after starting on dialysis. Only patients with complete data included in unadjusted and adjusted analyses; adjusted for a sex, PRD, type of RRT at start and period of start of RRT; b age at start of RRT, PRD, type of RRT at start and period of start of RRT; cage at start of RRT, sex, type of RRT at start and period of start of RRT; d age at start of RRT, sex, PRD and period of start of RRT; e age at start of RRT, sex, PRD and period of start of RRT