Table 2.

Top five most significantly (p < 0.05) overrepresented gene ontology (GO) terms and Kyoto encyclopedia of genes and genomes (KEGG) pathways represented by either hypo- or hypermethylated differentially methylated region (DMR)-associated genes implicated by Stress treatment compared to control (p < 0.01).

Hypomethylated	p-value	Hypermethylated	p-value
Term		Term
Molecular function
SUMO-specific protease activity	0.005	voltage-gated potassium channel activity in ventricular cardiac muscle cell action potential repolarization	4.96E-04
protein-arginine omega-N asymmetric methyltransferase activity	0.007	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization	0.002
nonmembrane spanning protein tyrosine kinase activity	0.009	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	0.004
histone-arginine N-methyltransferase activity	0.010	cytokine activity	0.006
arginine N-methyltransferase activity	0.014	peptidyl-proline 4-dioxygenase activity	0.006
Biological process
histone methylation	0.003	positive regulation of protein secretion	3.88E-04
smooth muscle contraction	0.005	regulation of macrophage cytokine production	0.001
apoptotic nuclear changes	0.007	ventricular cardiac muscle cell membrane repolarization	0.001
regulation of microtubule cytoskeleton organization	0.007	positive regulation of cytokine secretion	0.001
neuron projection extension in neuron projection guidance	0.007	cardiac muscle cell membrane repolarization	0.001
Cellular component
multivesicular body membrane	0.005	multivesicular body	0.025
T cell receptor complex	0.009	T cell receptor complex	0.045
actin cytoskeleton	0.017	platelet alpha granule	0.045
multivesicular body	0.021
cytoplasmic stress granule	0.024
KEGG pathway
Chemokine signaling pathway	0.020	Cytokine-cytokine receptor interaction	1.34E-06
		Neuroactive ligand-receptor interaction	0.008
		Antigen processing and presentation	0.013
		TGF-beta signaling pathway	0.013
		Hematopoietic cell lineage	0.015