Table 5.

Relevant genes through the complementary direction, increase (↑) or decrease (↓) of methylation and gene expression changes compared to control for genes differentially expressed with promoter differentially methylated regions (DMRs).

	Direction				Methylation				Expression
Group	Methylation	Gene expression	Number of genes	Gene name	DMR locus	fold change	p–value		beta	p–value
				Slc2a9	chr5:38481041-38481660	−1.80	0.006		2.576	0.005
		↑	2
	↓			Blvrb	chr5:38481041-38481660	−1.80	0.006		2.576	0.005
		↓	0	–	–	–	–		–	–
		–	632	–	–	–	–		–	–
Ethanol
				Eif4g1	chr16:20671221-20671520	inf	0.003		−3.487	0.008
		↓	2
	↑			Myo6	chr9:80164241-80164600	3.03	0.009		−3.625	0.001
		↑	0	–	–	–	–		–	–
		–	648	–	–	–	–		–	–
				Arpp21	chr9:112234421-112234980	−3.79	0.002		2.253	0.006
		↑	3	Mark2	chr19:7340121-7341000	−2.03	0.001		3.413	0.003
	↓			Rab33b	chr3:51485781-51486080	-inf	0.003		2.830	0.009
Stress		↓	2	–	–	–	–		–	–
		–	1070	–	–	–	–		–	–
		↓	1	Slc39a11	chr11:113567341-113567720	3.33	0.010		−2.768	0.009
	↑	↑	0	–	–	–	–		–	–
		–	425	–	–	–	–		–	–
				Arpp21	chr9:112184321-112185360	−1.05	0.006		2.663	0.001
		↑	3	Dlg3	chrX:100773301-100773560	-inf	0.009		3.123	0.001
	↓			Pinx1	chr14:63859301-63859580	-inf	0.007		0.439	0.005
		↓	2	–	–	–	–		–	–
Ethanol + Stress		–	467	–	–	–	–		–	–
				Slu7	chr11:43434381-43434620	inf	0.004		−0.459	0.007
		↓	2
	↑			Unc119	chr11:78341401-78341900	1.90	0.006		−3.900	0.004
		↑	1	–	–	–	–		–	–
		–	499	–	–	–	–		–	–

– Indicates data is not applicable or not provided for clarity.