FIGURE 2.

Overview of reciprocal augment of Hippo-YAP signaling and innate antiviral response. YAP/TAZ antagonizes the innate antiviral response by inhibiting the activation of TBK1 (a) or IRF3 (b). cTAZ inhibits STAT1 activation and ISGs production (c). NDR2 promotes the K63-linked polyubiquitination of RIG-I, potentiating the IFN-β production (d). NDR1 facilitates TBK1 activation by mediating the activation of GSK3β (e). MST1 mediates the degradation of IRAK1, a negative regulator for IFN-β production (f). MST1 inhibits IRF3 (g) and TBK1 (h), repressing IFN-β production. IKKε mediates the degradation of YAP (i) and LATS1/2 (j). Activated IRF3 induces the transcription of MST1 and the activation of Hippo pathway (k). Activated IRF3 interacts with YAP-TEAD complex and promote the activation of YAP (l). In general, Hippo-YAP signaling and innate antiviral signaling exhibit reciprocal activation. The interplays between Hippo-YAP and innate antiviral signaling are highlighted with red color.