FIGURE 1.

Participant flow diagram. Participant flow diagram for the Women's Health Initiative trial of a low-fat dietary pattern in women without hypertension or prior history of CVD at baseline but who reported intake of total fat above the median. All participants were postmenopausal and in the age range 50–79 y when enrolled during 1993–1998 at 40 US clinical centers. ¹Hypertension was defined as self-report of ever taking medication for hypertension before randomization, or clinic-measured systolic/diastolic blood pressure ≥140/90 mm Hg. ²Prior history of CVD was defined as self-report before randomization of MI, CABG/PCI, or stroke. ³Time-origin for Cox regression models began at year 1. ⁴Implausible energy intakes of <600 kcal/d or >5000 kcal/d. CABG/PCI, coronary artery bypass graft/percutaneous coronary intervention; CVD, cardiovascular disease; MI, myocardial infarction.