Table 3.
The Association between lymph node stage and thyroid cancer specific mortality. (SEER database years of 2004-2015).
| Group | Mortality | Unadjusted | Adjusteda | ||
|---|---|---|---|---|---|
| n/N (%) | HR (95%CI) | P | HR (95%CI) | P | |
| TC | |||||
| N0 | 388/831 (46.7) | Ref. | |||
| NX | 223/362 (61.6) | 1.71 (1.45-2.02) | <0.001 | 1.83 (1.46-2.31) | <0.001 |
| N1a | 124/268 (46.3) | 0.98 (0.80-1.19) | 0.808 | 1.07 (0.84-1.35) | 0.601 |
| N1b | 480/906 (53.0) | 0.74 (0.65-0.85) | <0.001 | 1.78 (1.52-2.10) | <0.001 |
| N1NOS | 115/214 (53.7) | 0.81 (0.65-1.00) | 0.045 | 1.46 (1.14-1.86) | 0.003 |
| PTC | |||||
| N0 | 113/360 (31.4) | Ref. | |||
| NX | 44/97 (45.4) | 1.68 (1.19-2.38) | 0.004 | 1.83 (1.10-3.02) | 0.019 |
| N1a | 45/158 (28.5) | 0.90 (0.64-1.27) | 0.557 | 1.04 (0.69-1.56) | 0.867 |
| N1b | 149/468 (31.8) | 1.02 (0.80-1.31) | 0.857 | 1.70 (1.27-2.29) | <0.001 |
| N1NOS | 27/100 (27.0) | 0.72 (0.47-1.11) | 0.137 | 0.85 (0.51-1.41) | 0.521 |
| FTC | |||||
| N0 | 73/194 (37.6) | Ref. | |||
| NX | 28/76 (36.8) | 1.21 (0.77-1.88) | 0.406 | 1.02 (0.53-1.96) | 0.956 |
| N1a | 11/17 (64.7) | 2.06 (1.09-3.89) | 0.026 | 2.33 (1.17-4.65) | 0.016 |
| N1b | 22/38 (57.9) | 2.09 (1.29-3.38) | 0.003 | 1.80 (0.98-3.31) | 0.057 |
| N1NOS | 7/10 (70.0) | 2.15 (0.99-4.70) | 0.055 | 1.95 (0.70-5.48) | 0.204 |
| ATC | |||||
| N0 | 83/89 (93.3) | Ref. | |||
| NX | 48/50 (96.0) | 1.25 (0.87-1.80) | 0.219 | 1.22 (0.79-1.89) | 0.374 |
| N1a | 34/40 (85.0) | 0.86 (0.58-1.28) | 0.455 | 0.85 (0.51-1.40) | 0.510 |
| N1b | 135/157 (86.0) | 1.08 (0.82-1.42) | 0.599 | 1.25 (0.91-1.73) | 0.171 |
| N1NOS | 37/42 (88.1) | 1.10 (0.75-1.63) | 0.622 | 1.11 (0.69-1.77) | 0.670 |
TC, thyroid cancer; PTC, papillary thyroid cancer; FTC, follicular thyroid cancer; ATC, anaplastic thyroid cancer; HR, hazard ratios; CI, confidence interval.
a
Adjusted for age, race, gender, and tumor size.